Digital health tools. Theory-driven. Evidence-based.

Digital health tools such as serious games, interactive apps and e-learnings can be a powerful and cost-effective way to educate and empower patients, family caregivers, or healthcare professionals. They can also help change behaviours and improve patient outcomes. Yet, despite major investments, most digital health tools fail.

Our validated SERES™ framework will help your digital health project succeed, whilst reducing your development cost and optimizing ROI. We’ve helped clients conceptualize, design and build evidence-based tools for oncology, mental health, cardiovascular disease, rheumatology, endocrinology and a range of orphan diseases.

Empower patients

Digital health tools can educate and empower patients. Whether you want to teach coping strategies, facilitate shared treatment decision-making, raise patient self-efficacy and self-management of the disease, we can help you!

Behaviour change

When designed well, digital health tools can realise long-term behaviour change. If you need innovative tools to improve medication compliance and treatment adherence, or induce appropriate behaviors, we’ve got you covered!

Improve outcomes

Digital health tools can be a cost-effective way to improve clinical, psychosocial or cognitive outcomes, as an adjunct or stand-alone intervention. We can help you research, design and clinically validate state-of-the-art digitals tools.


Our clinically validated SERES™ framework will help your project succeed.

We are science PhDs, designers and engineers with 10+ years of experience in the healthcare sector. We have a proven track record in designing scientifically founded, evidence-based digital health tools.1,2 Our clinically validated SERES™ framework3,4 will help your digital health project succeed, where others fail.


1. Matthyssens, L.E., Vanhulle, A., Seldenslach, L., Vander Stichele, G., Coppens, M., Van Hoecke, E. A pilot study of the effectiveness of a serious game CliniPup on perioperative anxiety and pain in children, J Pediatr Surg, 55(2), 2020, 304-311. doi:10.1016/j.jpedsurg.2019.10.031 2. Vass, C.M., Davison, N.J., Vander Stichele, G. et al. A Picture is Worth a Thousand Words: The Role of Survey Training Materials in Stated-Preference Studies. Patient (2019). doi.org/10.1007/s40271-019-00391-w 3. Verschueren S, et al. Developing Theory-Driven, Evidence-based Games for Health: Framework based on research community insights. JMIR Serious Games. 2019 May 2;7(2):e11565.  4. Buffel C, et al. A web-based serious game for health to reduce perioperative anxiety and pain in children (CliniPup): a pilot study. JMIR Serious Games. 2019;7(2):e12431.

We build strong scientific foundations

Our team of PhDs searches the literature and connects with experts

We connect with real life

We connect with users, doctors, patients and experts for insight and feedback.

We create compelling stories

We transform the science into immersive narratives.

We develop clever engines

We measure and capture key data for further research & analysis.

We transform through visual design

We use UX and information design principles to engage users and ensure they emotionally relate to your tool

Our evidence-based EDU-GRID aids in choosing the right type of educational tool.

Plenty possibilities

When developing educational tools, you can make plenty of variants. Some might even not see the forest for the trees: digital or on paper? Virtual reality or simple drawings?


Our evidence-based EDU-GRID tool facilitates this and provides transparent and actionable recommendations for optimal features, format/content and visual elements. For this purpose, we have examined relevant literature, HTA and regulatory requirements. Each type of educational tool suits better to a specific patient population, disease or treatment context. By answering questions in the EDU-GRID panel, researchers easily see which type of educational tool has potential to maximize participant engagement & understanding and therefore collect higher quality data.1


Patients are better informed, less biased, and they better reflect their preferences regarding treatment. Researchers from the University of Manchester have tested an educational tool developed using EDU-GRID.1 

1. Vass, C.M., Davison, N.J., Vander Stichele, G. et al. A Picture is Worth a Thousand Words: The Role of Survey Training Materials in Stated-Preference Studies. Patient (2019).  doi.org/10.1007/s40271-019-00391-w


MindBytes provides consultancy services to maximize the potential of your medical communication project, whether it be a digital health tool, paper communication, an explainer video, ...

Irrespective of your medium, we provide you with tailored, end-to-end services that result in a powerful and engaging end-product. Leveraging our experience in behaviour change, copywriting, intuitive design, and digital health tool development, we make sure your idea reaches its fullest potential.

Master programs

We guide you from idea to proof-of-concept (POC) and a minimally viable product (MVP) your target audience really wants and needs.

Workshops & training

Learn the methodology for designing effective digital health tools, designing for behavior change and gamification.

Services & expertise

We offer a wide range of services, such as literature review, user research, copy-writing, design, development and consultancy.


Strong collaborations with academic partners, patient organisations, pharma and hospitals.

We’ve had the opportunity to work with a range of industry clients and have ongoing collaborations with various academic partners, patient organisations and hospitals. To stay ahead of the curve, we also actively participate in international research projects. If you have a project you would like to collaborate on, we’d love to hear from you!

Academic and government

  • Academic Centre for General Practice (ACGP)
  • VLESP (Flemish Expertise Centre for Suicide Prevention)
  • KU Leuven
  • UZ Gent
  • Uppsala University
  • Manchester University
  • Hogeschool Gent

Grant projects

Many more

  • Alzheimer Liga
  • Christelijke Mutualiteiten (CM)
  • EBMPracticeNet
  • HealthConnect
  • Corilus
  • ICRI
  • Mintlab
  • and several leading Pharmaceutical and Biotech Companies


A wide variety of diseases and target populations.

We’ve developed digital health tools for a wide variety of therapeutic areas, including oncology, endocrinology, psychiatry, and orphan diseases. These tools were developed for patients, family caregivers and healthcare professionals. They focused on education, empowerment, improving decision-making and changing behaviors for the long-term. See our portfolio to learn more!


MindBytes' publications and academic disseminations

Over the years we have invested significantly in research and development. Together with our research collaborators, we have published numerous manuscripts, abstracts, and theses validating our methods and the impact of our evidence-based digital health tools. Explore our dissemination activities further below by clicking on the location points. (For optimal responsiveness, please use a computer).